Chronic Heart Failure
Empagliflozin Outcome Trial in Patients With Chronic Heart Failure With Preserved Ejection Fraction
The EMPEROR-Preserved trial evaluated the efficacy of empagliflozin, an SGLT2 inhibitor, in patients with chronic heart failure with preserved ejection fraction (HFpEF). This international, multicenter study included 5,998 participants and was conducted across 622 centers in 23 countries. Patients were randomized to receive either empagliflozin (10 mg daily) or a placebo, alongside standard care, over a median follow-up period of 26 months.
Key findings from the trial include a 21% reduction in the combined risk of cardiovascular death or hospitalization for heart failure among those treated with empagliflozin compared to placebo. The reduction in total heart failure hospitalizations was even more pronounced at 27%. These benefits were observed regardless of the presence of diabetes. Empagliflozin also slowed the decline in renal function compared to the placebo group, further highlighting its potential therapeutic advantages in HFpEF management
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Chronic Heart Failure Conference Speakers
Recommended Sessions
- AF Screening With a 14-Day ECG Monitor
- Cerebrovascular Disease & Stroke
- Heart failure and cardiomyopathies
- Acute Coronary Syndrome (ACS)
- Ageing
- Bladder and Bowel Health
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